A number of sides are hot on the heels of the top two and will be looking to take advantage of the Hatters' league break.
Jason Ainsley admitted Spennymoor Town might not be in a title race anymore following their recent ‘blip’.
A win against Alfreton Town would be the perfect way to reaffirm their play-off credentials.
Breathing down the Moors’ necks are Bradford (Park Avenue) who could creep into third if they take the spoils from their trip to Southport.
Kidderminster Harriers head to Brackley Town knowing a point would be enough to see them back in the top seven.
Leaders Chorley are going for three in a row and could extend their lead to seven points in the process against Leamington.
Ashton United have failed to find the net in each of their last three games and desperately need points – Blyth Spartans are in town looking to pile on the misery.
After a long break, FC United of Manchester will be hoping to pick up where they left off last time out.
The Rebels secured a huge win over AFC Telford a fortnight ago and head to Curzon Ashton with a positive feel about their survival hopes.
Guiseley will have on eye on proceedings at the Nash as they look to rein in Hereford.
Could one of Boston or York be a dark horse for the play-offs? One thing is for certain – defeat for either side would be a body blow to their chances.
Elsewhere, Darlington head to Nuneaton Borough looking for only their second win of the year.
Saturday's National League North fixtures:
Ashton United v Blyth Spartans
Brackley Town v Kidderminster Harriers
Chorley v Darlington
Curzon Ashton v FC United of Manchester
Hereford v Guiseley
Nuneaton Borough v Darlington
Southport v Bradford (Park Avenue)
Spennymoor Town v Alfreton Town
York City v Boston United