The former Exeter, Torquay United and Eastleigh defender has been chosen to take the Tigers forward.
He replaces Marc Richards, who left the club to take over at Hereford last week.
Todd says he can’t wait to get started on the night they beat Dorking Wanderers to reach the fourth qualifying round of the FA Cup.
Todd told the club’s official website: “I’m really excited about the challenge ahead, for me personally it’s a real honour with the club looking to come home, to think that I’ll be the man to do that.
“Even though it’s very much a family and volunteer run club, Gloucester are ambitious and you can tell that after meeting the board and hearing their vision for it.
“It is a blow obviously to the club with the previous manager leaving but that’s football and as one door closes another inevitably opens. With the vision the board have and me coming in, hopefully that will signal the start of a new era for the club.
"With my experiences, I believe I’ve got a lot to offer and I cannot wait to get started.”